Description

Methadone AP-HP 40mg

Methadone AP-HP 40mg is a prescription medication containing 40mg of methadone hydrochloride in each capsule.

The product is intended for use under specialist medical supervision and is associated with strict prescription and dispensing requirements. In France, Methadone AP-HP 40mg is supplied in packs of 7 capsules.

For complete official product information, see the French Medicines Database — Methadone AP-HP 40mg.

Methadone AP-HP 40mg Overview

Methadone is a long-acting opioid medication.

Methadone AP-HP capsules are used in France as part of medically supervised opioid-substitution treatment for appropriate patients.

Treatment involves medical, social, and psychological follow-up.

Because methadone is a potent opioid, it has important safety considerations, including the risk of respiratory depression, overdose, drug interactions, and dependence.

Active Ingredient

Active ingredient: Methadone hydrochloride

Strength: 40mg per capsule

Dosage form: Capsule

Pack size: 7 capsules

Prescription required: Yes

Product holder: Assistance Publique–Hôpitaux de Paris (AP-HP)

What Is Methadone AP-HP 40mg Used For?

Methadone AP-HP 40mg is used as part of substitution treatment for significant opioid dependence under appropriate medical supervision.

The French medicines database identifies the product as a controlled narcotic medicine with specialized prescription and dispensing requirements.

Methadone treatment should be individualized by a qualified healthcare professional.

Methadone AP-HP Prescription Information

Methadone AP-HP 40mg is a prescription-only medication.

French dispensing requirements include specialized prescribing procedures and controlled dispensing. The product is subject to particular monitoring requirements.

Patients should use methadone only when it has been prescribed for them.

Do not share methadone with another person.

For general information about prescription medicines, visit our Prescription Medication Guide.

Methadone AP-HP 40mg Dosage Information

Methadone dosing must be determined by the treating healthcare professional.

The correct dose depends on factors such as the patient’s treatment history, opioid tolerance, medical condition, other medicines, and response to treatment.

Do not increase, decrease, or change your methadone dose without medical supervision.

Because methadone can accumulate in the body, taking more than prescribed can increase the risk of serious toxicity and overdose.

Methadone AP-HP Side Effects

Methadone can cause side effects.

Possible effects include:

Drowsiness
Dizziness
Nausea
Vomiting
Constipation
Sweating
Dry mouth
Reduced alertness

More serious reactions can include severe sedation and breathing problems.

Contact your healthcare professional if you experience concerning or persistent symptoms.

Methadone AP-HP Safety Information

Methadone is a powerful opioid and requires careful medical supervision.

Taking more than prescribed can cause serious or potentially fatal respiratory depression.

Methadone can also interact with other medications.

Keep the medication securely stored and away from children.

Never share your prescription.

Methadone and Respiratory Depression

Methadone can slow breathing.

The risk can increase when methadone is combined with other medicines or substances that cause central nervous system depression.

These can include:

Benzodiazepines
Other opioids
Sedatives
Sleep medicines
Alcohol
Certain other prescription medications

Tell your healthcare professional about every medication and substance you use.

Methadone and Benzodiazepines

Combining methadone with benzodiazepines can increase sedation and the risk of respiratory depression.

Examples of benzodiazepine medications include:

Diazepam
Alprazolam
Clonazepam
Lorazepam

If you use a medication such as Valium 10mg (Diazepam), tell your healthcare professional before starting or changing methadone treatment.

Do not change either medication without professional guidance.

Methadone and Lyrica

Pregabalin can cause dizziness and sleepiness.

Combining pregabalin with an opioid such as methadone may increase central nervous system depression in some patients.

If you are taking Lyrica 300mg (Pregabalin), make sure your doctor and pharmacist know about it.

Methadone and Alcohol

Alcohol can increase the sedative effects of methadone.

Combining alcohol with methadone may increase the risk of excessive sedation and breathing problems.

Avoid alcohol unless your healthcare professional specifically advises you otherwise.

Methadone Drug Interactions

Methadone can interact with many medications.

Tell your doctor and pharmacist about:

Prescription medications
Over-the-counter medicines
Benzodiazepines
Other opioids
Antidepressants
Sleep medicines
Sedatives
Heart medications
Vitamins
Herbal supplements
Alcohol and other substances

For more information, visit our Medication Interaction Guide.

Methadone and Other Opioids

Methadone should not be combined with other opioid medications unless specifically directed by the treating healthcare professional.

If you are prescribed another opioid such as Oxycodone Medication, your healthcare professional needs to know.

Other opioid products in our medication information section include Morphine Medication Information and Fentanyl Patch Medication Information.

Methadone Dependence

Methadone can cause physical dependence.

Physical dependence means that the body adapts to continued exposure to the medication.

This does not mean treatment should be stopped suddenly.

Methadone treatment should be managed by the healthcare professional overseeing the patient’s treatment.

Methadone Withdrawal

Stopping methadone suddenly can cause withdrawal symptoms.

Possible symptoms may include:

Anxiety
Restlessness
Sweating
Muscle aches
Insomnia
Nausea
Vomiting
Abdominal discomfort

Do not stop methadone treatment without discussing the decision with your healthcare professional.

Methadone Overdose

Taking too much methadone can cause a life-threatening overdose.

Warning signs can include:

Extreme sleepiness
Slow or difficult breathing
Loss of consciousness
Very small pupils
Severe weakness
Coma

If an opioid overdose is suspected, seek emergency medical assistance immediately.

Naloxone may be used in emergency treatment for opioid overdose. Learn more about Naloxone Medication Information.

Methadone Storage

Keep methadone in a secure location.

Store it according to the instructions provided with the medication.

Keep it away from children and anyone for whom it was not prescribed.

Accidental ingestion can cause serious or potentially fatal opioid poisoning.

Methadone AP-HP Availability

Availability can depend on the country, pharmacy, prescription requirements, and applicable controlled-medicine regulations.

Methadone AP-HP 40mg is a specific French presentation. Patients should verify that the pharmacy is authorized to dispense the prescribed medication in their jurisdiction.

Do not substitute another methadone product or strength without instructions from the treating healthcare professional.

Methadone AP-HP 40mg Product Information

Product: Methadone AP-HP 40mg

Active ingredient: Methadone hydrochloride

Strength: 40mg

Dosage form: Capsule

Pack size: 7 capsules

Prescription status: Prescription-only controlled medication

Manufacturer/authorization holder: Assistance Publique–Hôpitaux de Paris (AP-HP)

Frequently Asked Questions

What is Methadone AP-HP 40mg?

Methadone AP-HP 40mg is a prescription capsule containing 40mg of methadone hydrochloride.

What is Methadone AP-HP used for?

In France, Methadone AP-HP is used as part of medically supervised substitution treatment for opioid dependence.

How much methadone is in each capsule?

Each Methadone AP-HP 40mg capsule contains 40mg of methadone hydrochloride.

How many capsules are in the package?

The listed presentation contains 7 capsules.

Is Methadone AP-HP 40mg a prescription medication?

Yes. It is subject to prescription and controlled-dispensing requirements in France.

Can methadone cause drowsiness?

Yes. Methadone can cause drowsiness and reduced alertness, particularly when treatment begins or when other sedating substances are involved.

Can methadone interact with other medications?

Yes. Methadone has important potential drug interactions. Tell your healthcare professional about all medicines and supplements you use.

Can methadone be taken with Valium?

Methadone and benzodiazepines such as diazepam can increase sedation and respiratory-depression risks. The combination should only be used under appropriate medical supervision.

Can methadone be taken with Lyrica?

Pregabalin can increase sedation when combined with opioids. Patients taking Lyrica 300mg should tell their healthcare professional before starting or changing methadone treatment.

Can methadone cause dependence?

Yes. Methadone can cause physical dependence. Treatment should be managed by a qualified healthcare professional.

Can methadone cause an overdose?

Yes. Taking too much methadone can cause severe respiratory depression, unconsciousness, coma, and death.

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Important Methadone AP-HP Safety Reminder

Methadone AP-HP 40mg is a potent prescription opioid that requires appropriate medical supervision.

Use it only as prescribed. Do not share it, change the dose yourself, or combine it with alcohol or other sedating medications without professional guidance.

If severe breathing difficulty, extreme sleepiness, loss of consciousness, or suspected opioid overdose occurs, seek emergency medical assistance immediately.

This page provides general educational information and does not replace advice from a qualified healthcare professional.

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