Description
Makatussin® Comp. Hustensirup 80ml
Makatussin® Comp. Hustensirup is a prescription cough medicine containing dihydrocodeine hydrochloride and diphenhydramine hydrochloride.
Each 5ml contains 10mg of dihydrocodeine hydrochloride and 15mg of diphenhydramine hydrochloride. The product is supplied in an 80ml bottle.
For complete official product information, see the Swissmedic Makatussin Comp. product information.
Makatussin Comp. 80ml Overview
Makatussin Comp. is an oral cough syrup containing an opioid cough suppressant together with diphenhydramine.
Because it contains an opioid ingredient, Makatussin Comp. has important prescription, safety, and interaction considerations.
It should be used only according to the directions provided by a qualified healthcare professional.
Active Ingredients
Dihydrocodeine hydrochloride: 10mg per 5ml
Diphenhydramine hydrochloride: 15mg per 5ml
Pack size: 80ml
Dosage form: Oral syrup
What Is Makatussin Comp. Used For?
Makatussin Comp. is used for certain cough conditions, including irritating cough.
The appropriate treatment depends on the cause and severity of the cough.
A healthcare professional should determine whether this medicine is appropriate for the individual patient.
Makatussin Comp. Prescription Information
Makatussin Comp. is a prescription medicine.
A valid prescription should be obtained from an appropriately qualified healthcare professional before use.
Do not use medication prescribed for another person.
For general prescription medication information, visit our Prescription Medication Guide.
Makatussin Comp. Dosage Information
The appropriate amount depends on factors such as age, medical condition, other medications, and the instructions provided by the prescriber.
Follow the dosage instructions supplied with your prescription.
Do not increase the amount or frequency without professional guidance.
If you are unsure about your prescribed dose, speak with your pharmacist before taking another dose.
Makatussin Comp. Side Effects
Makatussin Comp. may cause side effects.
Possible effects may include:
- Drowsiness
- Dizziness
- Reduced alertness
- Nausea
- Constipation
- Dry mouth
- Other opioid-related effects
Not everyone experiences the same effects.
Contact a healthcare professional if you experience severe, unexpected, or persistent symptoms.
Makatussin Comp. Safety Information
Makatussin Comp. contains an opioid ingredient.
Opioid medicines can cause serious breathing problems, particularly when taken in excessive amounts or together with other medicines that cause sedation.
Keep the medicine away from children and other people for whom it was not prescribed.
Never share prescription medication with another person.
Makatussin Comp. and Other Sedating Medicines
Makatussin Comp. may cause drowsiness and central nervous system depression.
Combining an opioid with benzodiazepines or other central nervous system depressants can increase the risk of severe sedation and respiratory depression.
Tell your healthcare professional about all medicines you take.
Patients taking medications such as Valium 10mg (diazepam) or other sedating medicines should discuss the combination with their healthcare professional before using Makatussin Comp.
Makatussin Comp. and Alcohol
Alcohol can increase sedation and other risks associated with opioid medicines.
Avoid combining Makatussin Comp. with alcohol unless your healthcare professional specifically advises you otherwise.
If you regularly consume alcohol, tell your healthcare professional before starting treatment.
Makatussin Comp. Drug Interactions
Makatussin Comp. can interact with other medications.
Tell your doctor or pharmacist about all medicines and supplements you use, including:
- Prescription medications
- Over-the-counter medicines
- Benzodiazepines
- Other opioids
- Sleep medications
- Sedating antihistamines
- Antidepressants
- Muscle relaxants
- Vitamins
- Herbal supplements
- Alcohol
For additional information about medication interactions, visit our Medication Interaction Guide.
Makatussin Comp. and Other Prescription Medicines
Your pharmacist should know about your complete medication list before dispensing Makatussin Comp.
For example, medicines that cause drowsiness may increase sedation when taken with an opioid cough medicine.
If you are currently using another prescription medication such as Lyrica 300mg (pregabalin), tell your doctor or pharmacist before using Makatussin Comp.
Makatussin Comp. and Pregnancy
The official product information includes pregnancy-related restrictions.
If you are pregnant, planning to become pregnant, or breastfeeding, speak with your healthcare professional before using Makatussin Comp.
Do not begin treatment during pregnancy without professional medical guidance.
Makatussin Comp. and Children
Makatussin Comp. has age-related restrictions.
Keep the product out of reach of children.
Accidental ingestion of an opioid-containing medicine can result in serious or potentially life-threatening effects.
Makatussin Comp. Storage
Store the product according to the instructions on the packaging.
Keep the bottle securely closed and away from children.
Do not use the medicine after its expiration date.
Makatussin Comp. Pharmacy Information
A pharmacy can provide assistance with:
- Prescription processing
- Product availability
- Prescription requirements
- Medication questions
- Drug interaction concerns
- Storage information
- Refills and pharmacy procedures
For additional pharmacy information, visit our Pharmacy Services page.
Makatussin Comp. Availability
Availability can vary depending on the pharmacy, location, prescription requirements, and current supply.
If your prescribed product is unavailable, ask the pharmacist about the appropriate next step.
Do not substitute another cough medicine or opioid product without professional guidance.
Frequently Asked Questions
What is Makatussin Comp.?
Makatussin Comp. is a prescription cough syrup containing dihydrocodeine hydrochloride and diphenhydramine hydrochloride.
What ingredients are in Makatussin Comp.?
Each 5ml contains 10mg of dihydrocodeine hydrochloride and 15mg of diphenhydramine hydrochloride.
What size is Makatussin Comp.?
The product described on this page is supplied in an 80ml bottle.
Is Makatussin Comp. a prescription medicine?
Yes. It is a prescription medicine containing an opioid ingredient.
Can Makatussin Comp. cause drowsiness?
Yes. Drowsiness and reduced alertness may occur because of its active ingredients.
Can Makatussin Comp. be taken with alcohol?
Alcohol can increase sedation and other risks. Discuss alcohol use with your healthcare professional.
Can Makatussin Comp. interact with other medicines?
Yes. It can interact with medicines that cause sedation and other medications. Tell your doctor and pharmacist about everything you take.
Can Makatussin Comp. be taken with benzodiazepines?
Combining an opioid with benzodiazepines can increase the risk of severe sedation and respiratory depression. Professional medical guidance is important before using the combination.
What should I do if Makatussin Comp. is unavailable?
Contact your pharmacist or prescribing healthcare professional. Do not replace it with another medicine without professional guidance.
Explore More Medication Information
For additional Maxson Pharmacy resources, visit:
- Medication Information Center
- Prescription Medication Guide
- Medication Interaction Guide
- Pharmacy Services
- Lyrica 300mg
- Valium 10mg
Important Makatussin Comp. Safety Reminder
Makatussin® Comp. contains an opioid ingredient and should be used only according to a valid prescription and professional medical instructions.
Do not share the medication. Keep it away from children and avoid combining it with alcohol, benzodiazepines, or other sedating medicines unless specifically directed by a healthcare professional.
This page provides general educational information and does not replace advice from a qualified healthcare professional.






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